In the year before he retires, Gregor Weber, a globally renowned Vermeer expert and flamboyant curator at the Rijksmuseum in Amsterdam, works on his big dream: the largest Vermeer exhibition ever. Together with Weber, a number of enthusiasts and experts go in search of what truly makes a Vermeer a Vermeer.

Tim Jenison, a Texas based inventor, attempts to solve one of the greatest mysteries in all art: How did Dutch Master Johannes Vermeer manage to paint so photo-realistically 150 years before the invention of photography? Spanning a decade, Jenison's adventure takes him to Holland, on a pilgrimage to the North coast of Yorkshire to meet artista David Hockney, and eventually even to Buckingham Palace. The epic research project Jenison embarques on is as extraordinary as what he discovers.

A young peasant maid working in the house of painter Johannes Vermeer becomes his talented assistant and the model for one of his most famous works.

Anna, a French actress, is approached by financial broker Mark in the Vermeer room of a New York gallery. However, romance does not ensue.

The genius Spanish painter Salvador Dalí undertakes an amazing journey through the unknown mental territories of Upper Mongolia in search of a giant hallucinogenic mushroom while paying an experimental tribute to the French poet Raymond Roussel (1877-1933), a visionary and eccentric writer, precursor of the surrealists and much admired by them.