Last Performance, the fifth feature film from award-winning European director Edwin Brienen, is set in the tumultuous New York theater world. Julia, a European actress who relocated to New York to try and make the big time, stars in an avant-garde theatre play, directed by the eccentric Magda. Inspired by obsessive philosophers such as Nietzsche, Schopenhauer and LaVey - "Forget the weak, the virtuous ones and the compassionate ones" - Magda explores the dark side of life. Julia's co-star, herein, is Cooper who has an abusive relationship with the sexually frustrated Tom. Tom, unable to accept his homosexuality, in turn exploits Julia for his own sexual adventures. Cooper, enraged by jealousy, sets out for revenge and his actions, herein, trigger an inexorable wave of disintegration and misery. Soon, fact and fiction become indistinguishable as Julia too becomes the author of her own demise.

Raina embarks on an affair with the tortured Nick. The compulsion towards excessive behaviour forms the nexus of their relationship. Isabelle is bound up in a lifeless marriage. The two women meet in a church. Their physical contact begins as a caress but ends in a fit of aggression.

A group of Amsterdam artists try to set up an erotic show in a Berlin nightclub. When the show flops, the group fades away into alcohol abuse and sexual excesses.

The film tells the story of six mental cases, trying to get rid of society's norms and values by kidnapping Gerard van Dongen, a well-known TV host. During an improvised TV show, the terrorists confront this Van Dongen with their darkest thoughts and emotions, resulting in violent excesses and extreme sexual behavior.